Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study.
| Autor: | Heeran MC; Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark.., Høgdall CK, Kjaer SK, Christensen L, Blaakaer J, Christensen IJ, Hogdall EV |
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| Jazyk: | angličtina |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2012 Oct; Vol. 120 (10), pp. 846-54. Date of Electronic Publication: 2012 May 10. |
| DOI: | 10.1111/j.1600-0463.2012.02913.x |
| Abstrakt: | The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients. (© 2012 The Authors APMIS © 2012 APMIS.) |
| Databáze: | MEDLINE |
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