| Autor: |
Mann SD; Medical Physics Graduate Program, Duke University, Durham, NC 27710, USA., Perez KL, McCracken EK, Shah JP, Wong TZ, Tornai MP |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of oncology [J Oncol] 2012; Vol. 2012, pp. 146943. Date of Electronic Publication: 2012 Aug 16. |
| DOI: |
10.1155/2012/146943 |
| Abstrakt: |
A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies were consented and imaged as part of this IRB-approved breast imaging study. For each of the seven subjects, one randomly selected breast was imaged prone-pendant using the dedicated, compact breast SPECT-CT system underneath the shielded patient support. Iteratively reconstructed and attenuation and/or scatter corrected images were coregistered; CT images were segmented into glandular and fatty tissue by three different methods; the average concentration of Sestamibi was determined from the SPECT data using the CT-based segmentation and previously established quantification techniques. Very minor differences between the segmentation methods were observed, and the results indicate an average image-based in vivo Sestamibi concentration of 0.10 ± 0.16 μCi/mL with no preferential uptake by glandular or fatty tissues. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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