The nexus of Aβ, aging, and sleep.

Autor: Gerstner JR; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. gerstner@upenn.edu, Perron IJ, Pack AI
Jazyk: angličtina
Zdroj: Science translational medicine [Sci Transl Med] 2012 Sep 05; Vol. 4 (150), pp. 150fs34.
DOI: 10.1126/scitranslmed.3004815
Abstrakt: Roh et al. report a positive feedback loop between sleep-wake irregularities and aggregation of β-amyloid peptide, suggesting that sleep alterations could be an early event in Alzheimer's disease.
Databáze: MEDLINE