| Autor: |
Janati AB; Center For Neurology, Fairfax, VA 22031, USA., Alghasab N, Osman A |
| Jazyk: |
angličtina |
| Zdroj: |
Case reports in neurological medicine [Case Rep Neurol Med] 2012; Vol. 2012, pp. 183252. Date of Electronic Publication: 2012 Jul 24. |
| DOI: |
10.1155/2012/183252 |
| Abstrakt: |
A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. The purpose of this paper is to warn physicians against combination therapy with carbamazepine and tricyclic antidepressants which may be conducive to neuroleptic malignant syndrome in susceptible patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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