Neuroestrogen, rapid action of estradiol, and GnRH neurons.

Autor: Terasawa E; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States. terasawa@primate.wisc.edu, Kenealy BP
Jazyk: angličtina
Zdroj: Frontiers in neuroendocrinology [Front Neuroendocrinol] 2012 Oct; Vol. 33 (4), pp. 364-75. Date of Electronic Publication: 2012 Aug 30.
DOI: 10.1016/j.yfrne.2012.08.001
Abstrakt: Estradiol plays a pivotal role in the control of GnRH neuronal function, hence female reproduction. A series of recent studies in our laboratory indicate that rapid excitatory actions of estradiol directly modify GnRH neuronal activity in primate GnRH neurons through GPR30 and STX-sensitive receptors. Similar rapid direct actions of estradiol through estrogen receptor beta are also described in mouse GnRH neurons. In this review, we propose two novel hypotheses as a possible physiological role of estradiol in primates. First, while ovarian estradiol initiates the preovulatory GnRH surge through interneurons expressing estrogen receptor alpha, rapid direct membrane-initiated action of estradiol may play a role in sustaining GnRH surge release for many hours. Second, locally produced neuroestrogens may contribute to pulsatile GnRH release. Either way, estradiol synthesized in interneurons in the hypothalamus may play a significant role in the control of the GnRH surge and/or pulsatility of GnRH release.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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