Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives.
| Autor: | Kumarasamy M; Department of Chemical Engineering, University of Rovira i Virgili, 26, Av. Paisos Catalans, Tarragona, Spain., Theivendren P, Govindarajan R, Franzblau SG, Ramalingam K |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2012 Jul; Vol. 4 (3), pp. 207-11. |
| DOI: | 10.4103/0975-7406.99035 |
| Abstrakt: | Aim: A novel series of N-nitroso-3-(substituted phenylimino)-indolin-2-one 3a-h was synthesized and tested for carcinogenic effects. Materials and Methods: The synthesized pyrazole derivatives' chemical structures were proved by means of their infra red (IR), proton nuclear magnetic resonance ((1)H-NMR), and mass,and confirmed by elemental analyses. The carcinogenic activity was assessed by 3-(4,5dimethyl thiazole-2yl)-2,5-diphenyltetrazoliumbromide (MTT) cell-viability assay. Results: The results show that most of the synthesized compounds exhibit significant carcinogenic activities. Among the synthesized compounds, N-nitroso-3-(2,4-dinitrophenylimino)-indolin-2-one 3h exhibited the most potent carcinogenic activity. Conclusion: The structure-activity relationship (SAR) studies show that the nature as well as the position of the amine are important for deciding the activity profile of the indolin-2-one derivatives, which reiterates the need for further experimental investigations. |
| Databáze: | MEDLINE |
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