Transport through liquid membranes containing omeprazole and lansoprazole.

Autor: Nagappa AN; Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031. anantha@bits-pilani.ac.in, Pandi PV, Mishra PK, Girish RK, Shanmukh I
Jazyk: angličtina
Zdroj: Indian journal of biochemistry & biophysics [Indian J Biochem Biophys] 2002 Dec; Vol. 39 (6), pp. 406-9.
Abstrakt: Omeprazole and lansoprazole, the therapeutically important drugs belonging to proton pump inhibitor category are extensively used in the treatment of gastric ulcers. Transport through liquid membranes generated by these drugs in lecithin-cholesterol mixture in series with a supporting membrane has been studied. The data obtained show the formation of liquid membrane in series with the supporting membrane. Transport of cations, chloride and bicarbonate ions in the presence liquid membranes generated by omeprazole and lanzoprazole indicate the modification in the permeability of various permeants.
Databáze: MEDLINE