LSD and 9,10-dihydro-LSD analyses in street drug blotter samples via easy ambient sonic-spray ionization mass spectrometry (EASI-MS).

Autor: Romão W; ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas-UNICAMP, Campinas, SP, Brazil. wandersonromao@gmail.com, Sabino BD, Bueno MI, Vaz BG, Júnior AC, Maldaner AO, de Castro EV, Lordeiro RA, Nascentes CC, Eberlin MN, Augusti R
Jazyk: angličtina
Zdroj: Journal of forensic sciences [J Forensic Sci] 2012 Sep; Vol. 57 (5), pp. 1307-12. Date of Electronic Publication: 2012 Aug 06.
DOI: 10.1111/j.1556-4029.2012.02237.x
Abstrakt: Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10-dihydro-LSD, an uncontrolled substance. In this work, easy ambient sonic-spray ionization mass spectrometry in the positive ion mode, EASI(+)-MS, was used to characterize LSD and 9,10-dihydro-LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high-performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI(+)-MS, 28 showed positive results for LSD, seven for 9,10-dihydro-LSD, and another six samples showed negative results for both LSD and 9,10-dihydro-LSD. The combination of thin layer chromatography with EASI-MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs.
(© 2012 American Academy of Forensic Sciences.)
Databáze: MEDLINE
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