| Autor: |
Taylor DT; Department of Mathematics, Virginia Commonwealth University, 1015 Floyd Avenue, Richmond, VA 23284-2014, USA., Cain JW, Bonchev DG, Fong SS, Apte AA, Pace LE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biological dynamics [J Biol Dyn] 2010 Mar; Vol. 4 (2), pp. 196-211. |
| DOI: |
10.1080/17513750903144461 |
| Abstrakt: |
A preceding study analysed how the topology of network motifs affects the overall rate of the underlying biochemical processes. Surprisingly, it was shown that topologically non-isomorphic motifs can still be isodynamic in the sense that they exhibit the exact same performance rate. Because of the high prevalence of feed-forward functional modules in biological networks, one may hypothesize that evolution tends to favour motifs with faster dynamics. As a step towards ranking the efficiency of feed-forward network motifs, we use a linear flow model to prove theorems establishing that certain classes of motifs are isodynamic. In partitioning the class of all motifs on n nodes into equivalence classes based upon their dynamics, we establish a basis for comparing the efficiency/performance rates of different motifs. The potential biological importance of the theorems is briefly discussed and is the subject of an ongoing large-scale project. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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