| Autor: |
Worley B; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America., Richard G, Harbison GS, Powers R |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2012; Vol. 7 (8), pp. e42075. Date of Electronic Publication: 2012 Aug 02. |
| DOI: |
10.1371/journal.pone.0042075 |
| Abstrakt: |
An n = π* interaction between neighboring carbonyl groups has been postulated to stabilize protein structures. Such an interaction would affect the (13)C chemical shielding of the carbonyl groups, whose paramagnetic component is dominated by n = π* and π = π* excitations. Model compound calculations indicate that both the interaction energetics and the chemical shielding of the carbonyl group are instead dominated by a classical dipole-dipole interaction. A set of high-resolution protein structures with associated carbonyl (13)C chemical shift assignments verifies this correlation and provides no evidence for an inter-carbonyl n = π* interaction. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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