| Autor: |
Eropkina EM, Il'inskaia EV, Litasova EV, Eropkin MIu, Piotrovskiĭ LB, Dumpis MA, Kiselev OI |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2012 May-Jun; Vol. 57 (3), pp. 468-75. |
| Abstrakt: |
In view of contradictory data on the toxicity of fullerenes for live organisms we studied the effect of water-soluble complexes of C60 with N-polyvivyl-pirrolidone (C60/PVP) and gamma-cyclodextrine (C60/gamma-CD) on MA-104 cells in culture. Both complexes proved to be non-toxic for cultured cells in the dark in wide range of concentrations. Both complexes provoke changes of cellular ultra-structure which reflect the enhancement of metabolic activity. At the same time only the exposition with the complex C60/PVP leads to the essential growth of number and size of mitochondria. However, the effect of two studied water-soluble forms of C60 under intensive UV-irradiation of cells proved to be opposite: C60/PVP had a cyto-protective action while C60/gamma-CD caused a significant growth of photo-toxicity. Possible reasons of the differences in the action of different forms of C60 on living organisms are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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