| Autor: |
Bondarenko TI; Southern Federal University, Rostov-on-Don, Russia. tomabon@yandex.ru, Sorokina IA, Mayboroda EA, Durkanaeva OA, Kutilin DS, Mikhaleva II |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Jul; Vol. 153 (3), pp. 371-4. |
| DOI: |
10.1007/s10517-012-1719-3 |
| Abstrakt: |
Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen>myocardium>testicles>liver>skeletal muscles) has been demonstrated. Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific. Delta sleep-inducing peptide exhibited a hypoglycemic effect: it prevented nonenzymatic glycosylation of hemoglobin and reduced the level of defective protein molecules during aging. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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