Changes in the levels of N-cadherin and PCNA in skin melanoma cells are mediated through matrix metalloproteinase 9.

Autor: Aksenenko MB; VV Ivanov Department of Pathophysiology with a Clinical Pathophysiology Course, VF VoinoYasenetsky State Medical University, Krasnoyarsk, Russia. aksenenko_mariya@mail.ru, Gyrylova SN, Ruksha TG
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Jul; Vol. 153 (3), pp. 364-6.
DOI: 10.1007/s10517-012-1717-5
Abstrakt: Immunohistochemical studies revealed increased level of matrix metalloproteinase 9 in skin melanoma cells. Inhibition of matrix metalloproteinase 9 with interfering RNA changed the level of PCNA and reduced N-cadherin content in melanoma cells. This attests to the involvement of matrix metalloproteinase 9 in the realization of invasion and metastatic growth and in the regulation of tumor growth and progress.
Databáze: MEDLINE
Externí odkaz: