Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats.
| Autor: | Dornelas CA; Department of Pathology, UFC, Ceara, Brazil. eusoucondor@yahoo.com.br, Fechine-Jamacaru FV, Albuquerque IL, Magalhães HI, Dias TA, Faria MH, Alves MK, Rabenhorst SH, de Almeida PR, Lemos TL, Castro JD, Moraes ME, Moraes MO |
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| Jazyk: | angličtina |
| Zdroj: | Acta cirurgica brasileira [Acta Cir Bras] 2012 Aug; Vol. 27 (8), pp. 529-36. |
| DOI: | 10.1590/s0102-86502012000800003 |
| Abstrakt: | Purpose: To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN). Methods: Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software. Results: The microvascular density in bladder carcinomas was lower (p<0.01) in rats receiving propolis than in controls given carcinogen only. On the other hand, the microvascular density of tumors in rats receiving carcinogen and L-lysine for 40 weeks from the beginning of carcinogen treatment was significantly higher (p<0.01) than in the corresponding controls. Conclusion: Water-soluble derivative of propolis inhibits angiogenesis in BBN-induced rat bladder cancer, while L-lysine treatment stimulates angiogenesis if initiated concurrently with BBN. |
| Databáze: | MEDLINE |
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