Vitamin C in plasma and leucocytes in relation to periodontitis.

Autor: Kuzmanova D; Department of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, The Netherlands., Jansen ID, Schoenmaker T, Nazmi K, Teeuw WJ, Bizzarro S, Loos BG, van der Velden U
Jazyk: angličtina
Zdroj: Journal of clinical periodontology [J Clin Periodontol] 2012 Oct; Vol. 39 (10), pp. 905-12. Date of Electronic Publication: 2012 Jul 30.
DOI: 10.1111/j.1600-051X.2012.01927.x
Abstrakt: Aim: To test the hypothesis that vitamin C concentrations in plasma, polymorphonuclear neutrophilic leucocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) are lower in periodontitis patients compared with healthy controls.
Methods: Twenty-one untreated periodontal patients and 21 healthy controls matched for age, gender, race and smoking habits were selected. Dietary vitamin C intake was assessed by a self-administered dietary record. Fasting blood samples were obtained and analysed for vitamin C concentrations in plasma, PMNs and PBMCs by means of high-pressure liquid chromatography (HPLC).
Results: Plasma vitamin C was lower in periodontitis patients compared with controls (8.3 and 11.3 mg/l, respectively, p = 0.03). Only in the control group a positive correlation was present between vitamin C intake and plasma values. No differences could be assessed between patients and controls regarding vitamin C dietary intake and levels in PMNs and PBMCs. In the patient group, pocket depth appeared to be negatively associated with the vitamin C concentration in PMNs.
Conclusion: Although the relationship between low plasma vitamin C levels and periodontitis is clear, the disease cannot be explained by insufficient vitamin C storage capacity of leucocytes; the question remains through which mechanism low plasma vitamin C levels are related to periodontitis.
(© 2012 John Wiley & Sons A/S.)
Databáze: MEDLINE
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