Control of innate and adaptive immunity by the inflammasome.
| Autor: | Ciraci C; Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Janczy JR, Sutterwala FS, Cassel SL |
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| Jazyk: | angličtina |
| Zdroj: | Microbes and infection [Microbes Infect] 2012 Nov; Vol. 14 (14), pp. 1263-70. Date of Electronic Publication: 2012 Jul 24. |
| DOI: | 10.1016/j.micinf.2012.07.007 |
| Abstrakt: | The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses. (Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.) |
| Databáze: | MEDLINE |
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