| Autor: |
Ferreira HV; Institute of Chemistry of São Carlos, University of São Paulo, Av. Trabalhador São-carlense 400, 13560-970 São Carlos, SP, Brazil., Rocha LC, Severino RP, Porto AL |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2012 Jul 26; Vol. 17 (8), pp. 8955-67. Date of Electronic Publication: 2012 Jul 26. |
| DOI: |
10.3390/molecules17088955 |
| Abstrakt: |
The lipase B from Candida antarctica (Novozym 435®, CALB) efficiently catalyzed the kinetic resolution of some aliphatic secondary alcohols: (±)-4-methylpentan-2-ol, (±)-5-methylhexan-2-ol, (±)-octan-2-ol, (±)-heptan-3-ol and (±)-oct-1-en-3-ol. The lipase showed excellent enantioselectivities in the transesterifications of racemic aliphatic secondary alcohols producing the enantiopure alcohols (>99% ee) and acetates (>99% ee) with good yields. Kinetic resolution of rac-alcohols was successfully achieved with CALB lipase using simple conditions, vinyl acetate as acylating agent, and hexane as non-polar solvent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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