| Autor: |
Mel'nik AI, Orlovskaia IV, Zholobak NM, Spivak NIa |
| Jazyk: |
ruština |
| Zdroj: |
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) [Mikrobiol Z] 2012 May-Jun; Vol. 74 (3), pp. 72-8. |
| Abstrakt: |
Technology for producing biologically active recombinant alpha2b-interferon is based on creating a bacterial producer strain containing the cDNA of human interferon alpha. The authors have obtained two producers of recombinant alpha2b-interferon, the synthesis of the target protein in them occurs in the inclusion bodies. The schemes of isolation and purification of biologically active recombinant alpha2b-interferon have been developed. The drug purity was approximately 97-98%. Biological activity in the culture of sensory cells in the cytopathic test was 4.2*10(8)ME/mg. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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