A NIR BODIPY dye bearing 3,4,4a-trihydroxanthene moieties.

Autor: Jiang XD; The Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Kaifeng, Henan 475004, China. xdjiang@henu.edu.cn, Gao R, Yue Y, Sun GT, Zhao W
Jazyk: angličtina
Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2012 Sep 14; Vol. 10 (34), pp. 6861-5. Date of Electronic Publication: 2012 Jul 25.
DOI: 10.1039/c2ob26218e
Abstrakt: A novel 3,4,4a-trihydroxanthene-fused pyrrole 2 was synthesized by the reaction of 2,3,4,4a-tetrahydro-1H-xanthen-1-one with 3-phenyl-2H-azirine in the presence of LDA. Utilizing this pyrrole 2, a NIR BODIPY 1 (λ(abs) = 732 nm, λ(em) = 747 nm) has been prepared. The new BODIPY 1 was stable, non-cytotoxic, and suited to labeling living cells for imaging assay in the NIR region.
Databáze: MEDLINE