Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense.

Autor: Shifrin DA Jr; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Tyska MJ
Jazyk: angličtina
Zdroj: Gut microbes [Gut Microbes] 2012 Sep-Oct; Vol. 3 (5), pp. 460-2. Date of Electronic Publication: 2012 Jul 24.
DOI: 10.4161/gmic.21247
Abstrakt: Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.
Databáze: MEDLINE