The deleterious effects of physical inactivity on elements of insulin resistance and metabolic syndrome in Central Africans at high cardiovascular risk.

Autor: Longo-Mbenza B; Walter Sisulu University, Faculty of Health Sciences PO BOX 1127, Mthatha, South Africa. longombenza@yahoo.fr, Nkongo Mvindu H, Kasiam On'kin JB, Bikuku N, Kianu Phanzu B, Nge Okwe A, Kabangu N
Jazyk: angličtina
Zdroj: Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2011 Jan-Mar; Vol. 5 (1), pp. 1-6. Date of Electronic Publication: 2010 Jun 09.
DOI: 10.1016/j.dsx.2010.05.001
Abstrakt: Aim: We aimed to describe the physical activity and to investigate the association between classical hypertension, obesity, diabetes, and new inflammation, IDF-defined metabolic syndrome, insulin resistance CV risk factors.
Design: This was a cross-sectional study based on interviews and physical and biochemistry measurements among Central African patients.
Measurements: Waist circumference (WC), blood pressure, weight and height to calculate body mass index (BMI), fasting glucose, CRP, ERS, uric acid, cholesterol (C), LDL-C, HDL-C, triglycerides, elements of homeostatic model assessment (HOMA) including insulin, HOMA index, QUICKI, insulin sensitivity (%S), beta-cell function (%β) and insulin resistance (IR).
Findings: Of the 60 patients included, 30 (50%) were physically inactive versus 30 (50%) active. In pooled analyses, in men and in women, there was significant and positive correlation between WC and seating/laying down position (WC=92.41+1.49 seating time in hours, R(2)=0.11; P<0.0001). The mean value of CRP and ERS were higher and those of all indices of HOMA were lower in inactive patients. The discriminant function for physical activity was Z (score=barycentre)=-7.36+1.013 HOMA index where -1.4 was the barycentre for active and +1.4 for inactive. HOMA index >2.42 was the optimal cut-off value to detect physically inactive patients: sensitivity=93.3%, specificity=100%, area under ROC=0.991±0.01 95%=0.975-1.0; P<0.0001.
Conclusion: The association between low-grade inflammation markers, insulin resistance and physical inactivity favours the hypothesis that a low-grade inflammatory status and enhanced insulin, sensitivity may constitute a part of the CV benefits from physical activity.
(Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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