The CD95 signaling pathway: To not die and fly.

Autor:	Penna A, Khadra N, Tauzin S, Vacher P, Legembre P
Jazyk:	angličtina
Zdroj:	Communicative & integrative biology [Commun Integr Biol] 2012 Mar 01; Vol. 5 (2), pp. 190-2.
DOI:	10.4161/cib.18888
Abstrakt:	Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss how m-CD95L and cl-CD95L diverging by their stoichiometry could both contribute to the immune response by first recruiting activated T lymphocytes in the inflamed area and later by eliminating infected and transformed cells.
Databáze:	MEDLINE
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