| Autor: |
Wu YR; Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Linkou, Taiwan. yihruwu@adm.cgmh.org.tw, Tan LC, Fu X, Chen CM, Au WL, Chen L, Chen YC, Prakash KM, Zheng Y, Lee-Chen GJ, Zhao Y, Zeng JS, Tan EK, Pei Z |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2012; Vol. 7 (7), pp. e36123. Date of Electronic Publication: 2012 Jul 10. |
| DOI: |
10.1371/journal.pone.0036123 |
| Abstrakt: |
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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