Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases.

Autor: Salimgareeva MKh; Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Moscow, Russia. milyausha78@mail.ru, Yamidanov RS, Vakhitova YV, Seredenin SB
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Jan; Vol. 152 (3), pp. 313-7.
DOI: 10.1007/s10517-012-1516-z
Abstrakt: We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats.
Databáze: MEDLINE