Synthesis, tautomeric structure and antimicrobial activity of 3-arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones.

Autor: Farghaly TA; Department of Chemistry, Faculty of Science, University of Cairo, Giza 12311, Egypt., Edrees MM, Mosselhi MA
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2012 Jul 13; Vol. 17 (7), pp. 8483-93. Date of Electronic Publication: 2012 Jul 13.
DOI: 10.3390/molecules17078483
Abstrakt: A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl-[1,2,4]triazepino[2,3-H]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
Databáze: MEDLINE