| Autor: |
Papadi B; Department of Pathology, University of South Alabama, Mobile, AL 36617, USA., Polski JM, Clarkson DR, Liu-Dumlao TO |
| Jazyk: |
angličtina |
| Zdroj: |
Virchows Archiv : an international journal of pathology [Virchows Arch] 2012 Sep; Vol. 461 (3), pp. 323-31. Date of Electronic Publication: 2012 Jul 12. |
| DOI: |
10.1007/s00428-012-1280-5 |
| Abstrakt: |
Angioimmunoblastic T cell lymphoma (AITL) is a relatively rare peripheral T cell lymphoma derived from follicular T helper cells. AITL has a varied presentation, both clinically and morphologically. AITL can pose a diagnostic challenge as it may be difficult to identify and characterize the neoplastic cells among the polymorphous infiltrates composed of polyclonal B immunoblasts and plasma cells. In AITL, the reactive B cell and plasma cell proliferation is secondary to dysregulated secretion of cytokines such as interleukin-6 by the neoplastic follicular T helper cells. SPBIP is a condition of unknown etiopathogenesis characterized by systemic involvement by polyclonal B immunoblasts and plasma cells. We report two cases of AITL, which are presented with atypical findings making it difficult to diagnose. The cases had features similar to SPBIP. Our cases highlight the importance of screening cases of polyclonal plasmacytosis and SPBIP like cases for underlying AITL. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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