Association of circulating endothelial progenitor cells (CD14+-EPC) with renal function in patients with coronary artery disease.

Autor:	Li GQ; 1The 2nd affiliated Hospital of Chongqing Medical University, Chongqing, China., Yang Y, Ke DZ, Li XS, Wu Q, Cao GY, Chen QW
Jazyk:	angličtina
Zdroj:	Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2013 Nov-Dec; Vol. 19 (6), pp. 632-6. Date of Electronic Publication: 2012 Jul 11.
DOI:	10.1177/1076029612447677
Abstrakt:	Background: The relationships between the endothelial progenitor cells (EPCs)-CD34(+) and CD14(+) and coronary artery disease (CAD) were reported and the association of CD34(+) cells with renal function was studied previously. Another kind EPC-CD14(+) cell and its association with renal function in patients with CAD have not been reported yet. Our aim was to assess CD14(+) cell counts versus renal function in CAD. Methods and Results: We studied 242 patients with severe angiographic CAD and 30 healthy control participants. The CD14(+) cells were enumerated by flow cytometry. With lowering glomerular filtration rate (GFR), CD14(+) cell numbers (percentage of lymphocytes, median and interquartile range) decreased: 0.04 (0.03-0.06), 0.03 (0.02-0.05), 0.02 (0.01-0.03) for estimated glomerular filtration rate (eGFR) ≥90, 60 to 89, and 30 to 89 mL/min per 1.73 m(2), respectively (P < .001 for trend). The CD14(+) cell counts correlated with eGFR (r = .27, P = .03). By multivariate liner regression analysis, the difference remains significant (P = .02). Conclusions: The CD14(+) cell depletion is associated with renal dysfunction in CAD.
Databáze:	MEDLINE
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