Predictive factors of early graft loss in living donor liver transplantation.
| Autor: | Alves RC; Department of Gastroenterology, Hospital do Servidor Público Estadual, São Paulo, SP, Brazil., Fonseca EA, Mattos CA, Abdalla S, Gonçalves JE, Waisberg J |
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| Jazyk: | angličtina |
| Zdroj: | Arquivos de gastroenterologia [Arq Gastroenterol] 2012 Apr-Jun; Vol. 49 (2), pp. 157-61. |
| DOI: | 10.1590/s0004-28032012000200011 |
| Abstrakt: | Context: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. Objective: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. Methods: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into >18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. Results: MELD score <18 (P<0.001) and serum sodium level > 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores > 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. Conclusions: MELD scores >18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation. |
| Databáze: | MEDLINE |
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