| Autor: |
Boswell RF Jr, Welstead WJ Jr, Duncan RL Jr, Johnson DN, Funderburk WH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1978 Jan; Vol. 21 (1), pp. 136-9. |
| DOI: |
10.1021/jm00199a029 |
| Abstrakt: |
In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as the end points. Most compounds were shown to be potent neuroleptic agents and two were found to possess a long duration of action. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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