[Study of protective properties of antigen-containing liposomes of different lipid composition in plague].
| Autor: | Zakrevskiĭ VI, Plekhanova NG |
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| Jazyk: | ruština |
| Zdroj: | Vestnik Akademii meditsinskikh nauk SSSR [Vestn Akad Med Nauk SSSR] 1990 (8), pp. 41-4. |
| Abstrakt: | Immunization of animals with a liposomal capsular and major somatic antigen of a plague causative agent enhanced their protective effects against plague infection. Lipopolysaccharide incorporation into the lipid membrane resulted in an increased protective effect of antigen-containing liposomes, which may be related to the single delivery and interaction with immune-competent cells. Incorporation of phospholipids with high phase transfer temperature and positively charged stearylamine by the membrane facilitates the immunogenicity of agents. |
| Databáze: | MEDLINE |
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