| Autor: |
de Tombe PP; Department of Cell and Molecular Physiology, Loyola University School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA., ter Keurs HE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of muscle research and cell motility [J Muscle Res Cell Motil] 2012 Dec; Vol. 33 (6), pp. 431-7. Date of Electronic Publication: 2012 Jun 30. |
| DOI: |
10.1007/s10974-012-9310-0 |
| Abstrakt: |
A classical paper published by Michael Barany almost 50 years ago demonstrated a tight correlation between the mechanical parameter of maximal velocity of shortening and the biochemical parameter of myosin ATPase activity in a wide spectrum of species. Here, we review the determinants of muscle dynamics by mechanical load and the relation between sarcomere shortening velocity and cross-bridge dynamics in rat myocardium containing a range of fast and slow myosin. Observations from molecular level to mechanics of the intact human heart suggest that cardiac actin-myosin kinetic properties are matched so as to optimize myocardial strain rate and allow for the maximum rate of hydraulic energy output observed during ejection in the whole ventricle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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