| Autor: |
Jagger BW; Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 2012 Jul 13; Vol. 337 (6091), pp. 199-204. Date of Electronic Publication: 2012 Jun 28. |
| DOI: |
10.1126/science.1222213 |
| Abstrakt: |
Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame ("X-ORF"), accessed via ribosomal frameshifting. The frameshift product, termed PA-X, comprises the endonuclease domain of the viral PA protein with a C-terminal domain encoded by the X-ORF and functions to repress cellular gene expression. PA-X also modulates IAV virulence in a mouse infection model, acting to decrease pathogenicity. Loss of PA-X expression leads to changes in the kinetics of the global host response, which notably includes increases in inflammatory, apoptotic, and T lymphocyte-signaling pathways. Thus, we have identified a previously unknown IAV protein that modulates the host response to infection, a finding with important implications for understanding IAV pathogenesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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