Effect of HMG-CoA reductase inhibitors on antimicrobial susceptibilities for gram-negative rods.

Autor: Farmer AR; Department of Medicine, San Antonio Military Medical Center, Fort Sam Houston, TX, USA. aaron.farmer@amedd.army.mil, Murray CK, Mende K, Akers KS, Zera WC, Beckius ML, Yun HC
Jazyk: angličtina
Zdroj: Journal of basic microbiology [J Basic Microbiol] 2013 Apr; Vol. 53 (4), pp. 336-9. Date of Electronic Publication: 2012 Jun 26.
DOI: 10.1002/jobm.201100614
Abstrakt: Epidemiologic evidence suggests a beneficial effect of HMG-CoA reductase inhibitors (statins) in sepsis, and in-vitro data exist for antimicrobial activity of statins against some bacteria and fungi. We examined whether statin exposure at physiologic concentrations enhances activity of selected antimicrobials against Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Broth microdilution was performed with and without dose-ranging concentrations of lovastatin, fluvastatin, atorvastatin, pravastatin and simvastatin. No effects on antimicrobial activity were demonstrated.
(© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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