| Autor: |
Sommariva M; Department of Human Morphology and Biomedical Sciences 'Città Studi'; Università degli Studi di Milano; Milan, Italy ; Molecular Targeting Unit Fondazione IRCCS; Istituto Nazionale Tumori; Milan, Italy., De Cecco L, Tagliabue E, Balsari A |
| Jazyk: |
angličtina |
| Zdroj: |
Oncoimmunology [Oncoimmunology] 2012 Mar 01; Vol. 1 (2), pp. 258-259. |
| DOI: |
10.4161/onci.1.2.18343 |
| Abstrakt: |
We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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