Effect of thiazide on rates of bone mineral loss: a longitudinal study.
| Autor: | Wasnich R; Hawaii Osteoporosis Center, Honolulu 96814., Davis J, Ross P, Vogel J |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | BMJ (Clinical research ed.) [BMJ] 1990 Dec 08; Vol. 301 (6764), pp. 1303-5. |
| DOI: | 10.1136/bmj.301.6764.1303 |
| Abstrakt: | Objective: To determine the effect of thiazide diuretic drugs on rates of bone mineral loss. Design: Longitudinal, observational study with a mean follow up of five years. Setting: Hawaii Osteoporosis Center, Honolulu. Subjects: 1017 Japanese-American men born between 1900 and 1920, of whom 378 were treated for hypertension (study group) and 639 did not have hypertension (control group). Intervention: Thiazide diuretics were taken by 325 men for a mean of 11.9 years; 53 men took antihypertensive drugs other than thiazides. Main Outcome Measure: Rate of bone loss estimated from serial photon absorptiometric scanning at three skeletal sites (calcaneus, distal radius, and proximal radius). Results: Rates of bone loss at all three sites were significantly reduced among thiazide users when compared with controls. The reductions in loss rate ranged from 28.8% (p = 0.02) (distal radius) to 49.2% (p = 0.0005) (calcaneus) relative to the controls. At all three sites the men taking other antihypertensive drugs had faster loss rates (22.6-43.1%) than those of the controls but the difference was significant only for the distal radius. Conclusion: Thiazide diuretics slow the rate of bone loss in elderly men. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|