The incidence of human herpes virus-8 expression in lymph node biopsies from human immunodeficiency virus-positive patients.
| Autor: | Beukes CA; Department of Anatomical Pathology, Faculty of Health Sciences, University of the Free State and National Health Laboratory Service, Bloemfontein, South Africa. beukesca@ufs.ac.za, Thiart J |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Histopathology [Histopathology] 2012 Nov; Vol. 61 (5), pp. 942-4. Date of Electronic Publication: 2012 Jun 20. |
| DOI: | 10.1111/j.1365-2559.2012.04291.x |
| Abstrakt: | Aims: Human immunodeficiency virus (HIV)-related lymphadenopathy is characterized by a wide spectrum of histological changes. Three patterns have been described which correspond to clinical stages of HIV/acquired immune deficiency syndrome (AIDS). Castleman disease is a heterogeneous group of disorders. A recently described variant, multicentric Castleman disease (MCD), of which some cases are associated with human herpes virus-8 (HHV-8), has been reported in both HIV-seropositive and -negative patients. Considerable morphological overlap occurs between one of the patterns of HIV lymphadenopathy and this variant. Methods and Results: This retrospective histopathological study on 95 cases of HIV-reactive lymphadenopathy assessed the incidence of the different patterns and HHV-8 on immunohistochemistry (IHC). Of the 95 cases, 78 (82.1%) were HHV-8-negative, of which 46 (59.0%) were classified as pattern A, 20 (25.6%) as pattern B and 12 (15.4%) as pattern C. Nine (31.0%) of 29 cases with pattern B and 8 (40.0%) of 20 cases with pattern C were HHV-8 positive. In total 15 cases of MCD were diagnosed in this series. Conclusion: This study draws attention to the overlap between HIV lymphadenopathy and MCD. We recommend that cases of HHV-8-associated MCD should be investigated for HIV infection. (© 2012 Blackwell Publishing Ltd.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|