Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics.
| Autor: | Villamena FA; Department of Pharmacology, & Davis Heart & Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, USA. frederick.villamena@osumc.edu, Das A, Nash KM |
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| Jazyk: | angličtina |
| Zdroj: | Future medicinal chemistry [Future Med Chem] 2012 Jun; Vol. 4 (9), pp. 1171-207. |
| DOI: | 10.4155/fmc.12.74 |
| Abstrakt: | Nitrone therapeutics has been employed in the treatment of oxidative stress-related diseases such as neurodegeneration, cardiovascular disease and cancer. The nitrone-based compound NXY-059, which is the first drug to reach clinical trials for the treatment of acute ischemic stroke, has provided promise for the development of more robust pharmacological agents. However, the specific mechanism of nitrone bioactivity remains unclear. In this review, we present a variety of nitrone chemistry and biological activity that could be implicated for the nitrone's pharmacological activity. The chemistries of spin trapping and spin adduct reveal insights on the possible roles of nitrones for altering cellular redox status through radical scavenging or nitric oxide donation, and their biological effects are presented. An interdisciplinary approach towards the development of novel synthetic antioxidants with improved pharmacological properties encompassing theoretical, synthetic, biochemical and in vitro/in vivo studies is covered. Competing Interests: Financial & competing interests disclosure The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. |
| Databáze: | MEDLINE |
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