| Autor: |
Couri BM; Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue ND20 Cleveland, OH 44195, USA., Lenis AT, Borazjani A, Paraiso MF, Damaser MS |
| Jazyk: |
angličtina |
| Zdroj: |
Expert review of obstetrics & gynecology [Expert Rev Obstet Gynecol] 2012 May 01; Vol. 7 (3), pp. 249-260. |
| DOI: |
10.1586/eog.12.24 |
| Abstrakt: |
Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has high prevalence worldwide and represents a great burden to the economy. The pathophysiology of pelvic organ prolapse is multifactorial and includes genetic predisposition, aberrant connective tissue, obesity, advancing age, vaginal delivery and other risk factors. Owing to the long course prior to patients becoming symptomatic and ethical questions surrounding human studies, animal models are necessary and useful. These models can mimic different human characteristics - histological, anatomical or hormonal, but none present all of the characteristics at the same time. Major animal models include knockout mice, rats, sheep, rabbits and nonhuman primates. In this article we discuss different animal models and their utility for investigating the natural progression of pelvic organ prolapse pathophysiology and novel treatment approaches. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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