Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial.

Autor: Tajik P; Academic Medical Centre, Amsterdam, the Netherlands. p.tajik@amc.uva.nl, van der Tuuk K, Koopmans CM, Groen H, van Pampus MG, van der Berg PP, van der Post JA, van Loon AJ, de Groot CJ, Kwee A, Huisjes AJ, van Beek E, Papatsonis DN, Bloemenkamp KW, van Unnik GA, Porath M, Rijnders RJ, Stigter RH, de Boer K, Scheepers HC, Zwinderman AH, Bossuyt PM, Mol BW
Jazyk: angličtina
Zdroj: BJOG : an international journal of obstetrics and gynaecology [BJOG] 2012 Aug; Vol. 119 (9), pp. 1123-30. Date of Electronic Publication: 2012 Jun 18.
DOI: 10.1111/j.1471-0528.2012.03405.x
Abstrakt: Objective: To examine whether cervical favourability (measured by cervical length and the Bishop score) should inform obstetricians' decision regarding labour induction for women with gestational hypertension or mild pre-eclampsia at term.
Design: A post hoc analysis of the Hypertension and Pre-eclampsia Intervention Trial At Term (HYPITAT).
Setting: Obstetric departments of six university and 32 teaching and district hospitals in the Netherlands.
Population: A total of 756 women diagnosed with gestational hypertension or pre-eclampsia between 36 + 0 and 41 + 0 weeks of gestation randomly allocated to induction of labour or expectant management.
Methods: Data were analysed using logistic regression modelling.
Main Outcome Measures: The occurrence of a high-risk maternal situation defined as either maternal complications or progression to severe disease. Secondary outcomes were caesarean delivery and adverse neonatal outcomes.
Results: The superiority of labour induction in preventing high-risk situations in women with gestational hypertension or mild pre-eclampsia at term varied significantly according to cervical favourability. In women who were managed expectantly, the longer the cervix the higher the risk of developing maternal high-risk situations, whereas in women in whom labour was induced, cervical length was not associated with a higher probability of maternal high-risk situations (test of interaction P = 0.03). Similarly, the beneficial effect of labour induction on reducing the caesarean section rate was stronger in women with an unfavourable cervix.
Conclusion: Against widely held opinion, our exploratory analysis showed that women with gestational hypertension or mild pre-eclampsia at term who have an unfavourable cervix benefited more from labour induction than other women.
Trial Registration: The trial has been registered in the clinical trial register as ISRCTN08132825.
(© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.)
Databáze: MEDLINE
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