| Autor: |
Gildner PG; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA., Gietter AA, Cui D, Watson DA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2012 Jun 20; Vol. 134 (24), pp. 9942-5. Date of Electronic Publication: 2012 Jun 12. |
| DOI: |
10.1021/ja304561c |
| Abstrakt: |
The C-alkylation of nitroalkanes under mild conditions has been a significant challenge in organic synthesis for more than a century. Herein we report a simple Cu(I) catalyst, generated in situ, that is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process, which we believe proceeds via a thermal redox mechanism, allows access to a variety of complex nitroalkanes under mild reaction conditions and represents the first step toward the development of a general catalytic system for the alkylation of nitroalkanes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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