| Autor: |
Nohara T; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan. none@ph.sojo-u.ac.jp, Kiyota Y, Sakamoto T, Manabe H, Ono M, Ikeda T, Fujiwara Y, Nakano D, Kinjo J |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2012; Vol. 60 (6), pp. 747-51. |
| DOI: |
10.1248/cpb.60.747 |
| Abstrakt: |
Several novel sulfides from acetone extracts of bulbs of garlic (Allium sativum L.), were identified and investigated. These were named garlicnins B(1) (1), C(1) (2), and D (3), and they were found to have the ability to control macrophage activation. Garlicnins B(1) (1) and C(1) (2) possess a new skeleton of cyclic sulfoxide and their structures of garlicnins B(1) (1) and C(1) (2) were characterized as 3,4-dimethyltetrahydrothiophene-S-oxide derivatives carrying the substitutions of a propenyl and a sulfenic acid, and an allyldithiine and a 1-propene-sulfenic acid (a), respectively. The mechanism of the proposed production of these compounds is discussed. Garlicnin D (3), dithiine-type, was estimated to be derived by addition of (a)+allyl thiosulfenic acid (b) derived from allicin. The identification of these novel sufoxides from onion and garlic accumulates a great deal of new chemistry to the Allium sulfide field, and future pharmacological investigations aid the development of natural, healthy foods and anti-cancer agents that could potentially prevent or combat disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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