| Autor: |
Xu HJ; Institut de Chimie Moléculaire, CNRS UMR6302, Université de Bourgogne, Dijon, France., Stefan L, Haudecoeur R, Vuong S, Richard P, Denat F, Barbe JM, Gros CP, Monchaud D |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2012 Jul 21; Vol. 10 (27), pp. 5212-8. Date of Electronic Publication: 2012 Jun 12. |
| DOI: |
10.1039/c2ob25601k |
| Abstrakt: |
Template-assembled synthetic G-quartet (TASQ) has been reported recently as a G-quadruplex ligand interacting with DNA according to an unprecedented, nature-inspired 'like likes like' approach, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand). Herein, a novel TASQ-based ligand is designed, synthesized and its quadruplex-recognition properties are evaluated in vitro: PorphySQ (for porphyrin-templated synthetic G-quartet) displays enhanced quadruplex recognition properties as compared to the very first reported prototype (DOTASQ, for DOTA-templated synthetic G-quartet), since the porphyrin template insures a more stable intramolecular G-quartet fold due to self-stabilizing interactions that may take place intramolecularly between the porphyrin ring and the formed G-quartet. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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