Mechanisms of developmental robustness.
| Autor: | Gursky VV; Theoretical Department, Ioffe Physical-Technical Institute of the Russian Academy of Sciences, St. Petersburg, 194021, Russia. gursky@math.ioffe.ru, Surkova SY, Samsonova MG |
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| Jazyk: | angličtina |
| Zdroj: | Bio Systems [Biosystems] 2012 Sep; Vol. 109 (3), pp. 329-35. Date of Electronic Publication: 2012 Jun 09. |
| DOI: | 10.1016/j.biosystems.2012.05.013 |
| Abstrakt: | We present a review of noise buffering mechanisms responsible for developmental robustness. We focus on functions of chaperone Hsp90, miRNA, and cross-regulation of gap genes in Drosophila. The noise buffering mechanisms associated with these functions represent specific examples of the developmental canalization, reducing the phenotypical variability in presence of either genetic or environmental perturbations. We demonstrate that robustness often appears as a function of a network of interacting elements and that the system level approach is needed to understand the mechanisms of noise filtering. (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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