Similar autobiographical memory impairment in long-term secondary progressive multiple sclerosis and Alzheimer's disease.
| Autor: | Müller S; Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany., Saur R, Greve B, Melms A, Hautzinger M, Fallgatter AJ, Leyhe T |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2013 Feb; Vol. 19 (2), pp. 225-32. Date of Electronic Publication: 2012 Jun 08. |
| DOI: | 10.1177/1352458512450352 |
| Abstrakt: | Background: Memory disturbance is a common symptom of multiple sclerosis (MS), but little is known about autobiographical memory deficits in the long-term course of different MS subtypes. Inflammatory activity and demyelination is pronounced in relapsing-remitting multiple sclerosis (RRMS) whereas, similar to Alzheimer's disease, neurodegeneration affecting autobiographical memory-associated areas is seen in secondary progressive multiple sclerosis (SPMS). Objective: In light of distinct disease mechanisms, we evaluated autobiographical memory in different MS subtypes and hypothesized similarities between elderly patients with SPMS and Alzheimer's disease. Methods: We used the Autobiographical Memory Interview to assess episodic and semantic autobiographical memory in 112 education- and gender-matched participants, including healthy controls and patients with RRMS, SPMS, amnesic mild cognitive impairment (aMCI) and early Alzheimer's dementia (AD). Results: Patients with SPMS, AD, and aMCI, but not with RRMS, exhibited a pattern of episodic autobiographical memory impairment that followed Ribot's Law; older memories were better preserved than more recent memories. In contrast to aMCI and AD, neither SPMS nor RRMS was associated with semantic autobiographical memory impairment. Conclusion: Our neuropsychological findings suggest that episodic autobiographical memory is affected in long-term patients with SPMS, possibly due to neurodegenerative processes in functional relevant brain regions. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|