| Autor: |
Hauswirth AW; Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer/IBMCC, University of Salamanca, Salamanca, Spain., Almeida J, Nieto WG, Teodosio C, Rodriguez-Caballero A, Romero A, López A, Fernandez-Navarro P, Vega T, Perez-Andres M, Valent P, Jäger U, Orfao A |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of hematology [Am J Hematol] 2012 Jul; Vol. 87 (7), pp. 721-4. Date of Electronic Publication: 2012 Jun 08. |
| DOI: |
10.1002/ajh.23214 |
| Abstrakt: |
Monoclonal B-cell lymphocytosis (MBL) with normal lymphocyte counts is associated with decreased numbers of normal circulating B-cell subsets.Little is known about the distribution of normal lymphoid cells and their subsets in the peripheral blood (PB) of subjects with monoclonal B-cell lymphocytosis (MBL). In our study, we compared the absolute number of PB lymphoid cells and their subpopulations in 95 MBL cases with normal lymphocyte counts vs. 617 age-/sex-matched non-MBL healthy subjects (controls), using highly sensitive flow cytometry. MBL cases showed significantly reduced numbers of normal circulating B-cells, at the expense of immature and naive B-cells; in addition, CD4+CD8+ double-positive T-cells and CD8+ T-cells were significantly lower and higher vs. controls, respectively. Moreover, most normal B-cell subsets were significantly decreased in PB at >1% MBL-counts, vs. "low-count" MBL cases, and lower amounts of immature/naive B-cells were detected in biclonal (particularly in cases with coexisting CLL-like- and non-CLL-like B-cell clones) vs. monoclonal MBL subjects. In summary, our results show imbalanced (reduced) absolute numbers of recently produced normal circulating B-cells (e.g., immature and naıve B-cells) in MBL, which becomes more pronounced as the MBL cell count increases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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