Exercise training, genetics and type 2 diabetes-related phenotypes.
| Autor: | Hagberg JM; Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA. hagberg@umd.edu, Jenkins NT, Spangenburg E |
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| Jazyk: | angličtina |
| Zdroj: | Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2012 Aug; Vol. 205 (4), pp. 456-71. |
| DOI: | 10.1111/j.1748-1716.2012.02455.x |
| Abstrakt: | Type 2 diabetes mellitus (T2DM) is at virtually pandemic levels world-wide. Diabetes has been referred to as 'a geneticist's nightmare'. However, dramatic advances in our understanding of the genetics of T2DM have occurred in the past 5 years. While endurance exercise training and increased habitual physical activity levels have consistently been shown to improve or be associated with improved T2DM-related phenotypes, there is substantial interindividual variation in these responses. There is some evidence that T2DM-related phenotype responses to exercise training are heritable, indicating that they might have a genetic basis. Genome-wide linkage studies have not identified specific chromosomal loci that could account for these differences, and no genome-wide association studies have been performed relative to T2DM-related phenotype responses to exercise training. From candidate gene studies, there are relatively strong and replicated data supporting a role for the PPARγ Pro12Ala variant in the interindividual differences in T2DM-related phenotype responses to training. This is a potentially important candidate locus because it affects T2DM susceptibility, has high biological plausibility and is the target for the primary pharmaceutical method for treating T2DM. Is it time to conduct a hypothesis-driven large-scale exercise training intervention trial based on PPARγ Pro12Ala genotype with T2DM-related phenotypes as the primary outcome measures, while also assessing potential mechanistic changes in skeletal muscle and adipose tissue? Or would it be more appropriate to propose a smaller trial to address the specific skeletal muscle and adipose tissue mechanisms affected by the interaction between the PPARγ Pro12Ala genotype and exercise training? (© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.) |
| Databáze: | MEDLINE |
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