Characterization of MLS(b) resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types.

Autor: Teodoro CR; Department of Medical Microbiology, Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Mattos CS, Cavalcante FS, Pereira EM, dos Santos KR
Jazyk: angličtina
Zdroj: Microbiology and immunology [Microbiol Immunol] 2012 Sep; Vol. 56 (9), pp. 647-50.
DOI: 10.1111/j.1348-0421.2012.00481.x
Abstrakt: This work characterizes MLS(b) resistance in 39 methicillin-resistant Staphylococcus aureus (MRSA) and 32 Staphylococcus epidermidis (MRSE) isolates. Of 21 erm(A) gene encoding MRSA isolates, 71.4% carried SCCmecIII, whereas of 12 isolates carrying the erm(C) gene, 83.3% carried SCCmecIV. Among the 25 MRSE isolates positive for the erm(C) gene, 80% had SCCmecIV or nontypeable cassettes. Isolates carrying these genes had MIC(90) ≥ 256 μg/mL to erythromycin and clindamycin. The msr(A) gene was associated with a low MIC(90) to these drugs. The erm(A) gene was associated with SCCmecIII in MRSA isolates, whereas the erm(C) gene was associated with SCCmecIV in both MRSA and MRSE isolates.
(© 2012 The Societies and Wiley Publishing Asia Pty Ltd.)
Databáze: MEDLINE
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