Tumor-specific MAGE proteins as regulators of p53 function.
| Autor: | Ladelfa MF; Departamento de Química Biológica, FCEN, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina., Peche LY, Toledo MF, Laiseca JE, Schneider C, Monte M |
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| Jazyk: | angličtina |
| Zdroj: | Cancer letters [Cancer Lett] 2012 Dec 01; Vol. 325 (1), pp. 11-7. Date of Electronic Publication: 2012 Jun 01. |
| DOI: | 10.1016/j.canlet.2012.05.031 |
| Abstrakt: | Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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