| Autor: |
Alexandrova LA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences., Shmalenyuk ER, Kochetkov SN, Erokhin VV, Smirnova TG, Andreevskaia SN, Chernousova LN |
| Jazyk: |
angličtina |
| Zdroj: |
Acta naturae [Acta Naturae] 2010 Apr; Vol. 2 (1), pp. 108-11. |
| Abstrakt: |
The WHO has declared tuberculosis (TB) a global health emergency. Therefore, there is an urgent need to discover and develop new anti-TB drugs. Here we report on a new category of 5-substituted pyrimidine nucleosides as potent inhibitors of Myco-bacterium tuberculosis growth in vitro. A series of 2'-deoxy-, 3'-azido-2',3'-dideoxy-, and 3'-amino-2',3'-dideoxypyrimidine nucleoside analogues bearing lengthy flexible alkyloxymethyl substituents exhibited marked inhibitory activity against M. tuberculosis in vitro. 5-Dodecyloxymethyl-2'-deoxyuridine was found to be a potent inhibitor of M. tuberculosis propagation in vitro. In contrast, monophosphates of the tested nucleosides were devoid of antimycobacterial activity. This new class of inhibitors seems to be a promising chemotherapeutic agent against TB and merits further studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
