The successful treatment of IgG4-positive colitis with adalimumab in a patient with IgG4-related sclerosing disease--a new subtype of aggressive colitis?
| Autor: | Naghibi M; Department of Gastroenterology, Hampshire Hospitals NHS Foundation Trust, Winchester, United Kingdom., Ahmed A, al Badri AM, Bateman AC, Shepherd HA, Gordon JN |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Crohn's & colitis [J Crohns Colitis] 2013 Apr; Vol. 7 (3), pp. e81-4. Date of Electronic Publication: 2012 May 29. |
| DOI: | 10.1016/j.crohns.2012.05.003 |
| Abstrakt: | We present the case of a 16 year old girl who developed an aggressive colitis in the context of a prior biopsy proven autoimmune pancreatitis, which presented with obstructive jaundice at the age of 13 year. This history prompted prospective investigation and the discovery of compelling evidence to make a diagnosis of IgG4-related sclerosing disease with extra-pancreatic colonic involvement on the basis of raised serum IgG4 levels and a florid colonic IgG4 plasma cell infiltrate with over 20 IgG4 positive plasma cells/hpf. The colitis was resistant to conventional therapy but responded dramatically to treatment with the anti-TNFα monoclonal antibody, adalimumab. This is the first case to report both the effectiveness of adalimumab in treating IgG4 positive colitis in a patient with IgG4-related sclerosing disease, and to prospectively record resolution of an IgG4 positive colonic infiltrate with immunosuppression. (Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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